Good grief, Charlie Brown!
The likelihood of running over a large enough bump to jostle your laptop while it is doing a drive read/write is so high to me that it musy be said. The kump up may not be all that horrible but the relative G forces seem to me to be more than high enough to cause a head crash. Go ahead do a kernel build and ride down not over some rail road ties. I am sure this will cause you the aforementioned grief.
Seriously, I do not recommend anyone to ride a bicycle or other somewhat unstable device (unicycle, roller skate, blades, skateboard, etc) while computing on a laptop. I have dealt with many head crashes from laptops that were dropped while stationary so I do not see that having a recent drive would make any real difference as the basics of HDD haven't changed that much in the past 30 years.