My current setup uses a 120 GB SSD for the OS and programs which are frequently used or need the high read/write speeds, and a 1 TB SSHD (8 GB cache) for user data and infrequently used or less I/O-intensive programs. Getting and keeping things arranged properly is just a bit tricky, and does occasionally require you to remember that not everything is (or belongs on) C:, but the system performs extremely well with this configuration.
Users with good hearing should be made aware of how SSHDs handle power management though, especially for this sort of configuration. Since the SSHD in this setup doesn't contain a lot of frequently-used data, it's very common for the system to reach a state where all of the data it needs is either on the SSD or loaded into the cache of the SSHD. When this happens, some SSHD drives will put the mechanical portion into an idle state - meaning the drive will spin down and the read/write heads will park. If you're in a quiet room, or have particularly sensitive ears, you will likely be able to hear the drive click when this happens. If you've got really good hearing, you may even notice when it spins back up. Rest assured that this is normal behavior and, unless it's happening excessively or the drive shows other symptoms of malfunction, does not generally mean there's something wrong with your drive.