This is what I have done for years and I have never lost any data. I use my system for home and business purposes.
I use local and cloud backups. Everything runs automatically.
For my basic computers, I have a system drive and a data drive in the PC's.
I back up data automatically, using Genie TimeLine Professional (They have a Free version), to a NAS unit daily which uses RAID 5 on my home network.
I have a second NAS unit (RAID5) that replicates the 1st NAS daily.
I know having 2 NAS units seems a bit overkill, but I had an experience with a bad firmware update that took the first NAS out of service. The manufacturer pulled the update.
Next I use Ghost to image the entire PC's, system and data drives on to external eSata hard drives. Ghost imaging runs automatically once a week. The drive retains an original clean vanilla image, and 4 complete images at any time. I have Ghost configured to run a monthly backup to retain 12 months of data backups.
Review and TEST the backups regularly.
I also use Dropbox and Skydrive for cloud access to any device. All the data I want available online is kept in Truecrypt encrypted containers that protect all my documents. No worries due to, oops we've been compromised!
I also use Scooter's "Beyond Compare" and Auslogic's "Duplicate File Finder" to keep file duplication (other than backup copies) to a minimum.